DEFEND | Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate

Name: DEFEND | Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate
Brand: amerín
SKU: 1004
Price: 57.00 USD
Availability: InStock

Benefits: peptide recover + smoother-looking skin | Skin type: normal to dry | Usage: evening

A nourishing night cream with Matrixyl™ 3000, cranberry oil, jojoba oil, safflower oil, shea butter, squalane and sodium hyaluronate. Helps skin feel softer, smoother, more hydrated and more comfortable by morning.

Helps soften the appearance of fine lines and uneven texture
Supports smoother, more supple and firmer-looking skin
Provides rich overnight nourishment and comfort
Helps replenish hydration with Glycerin, Sodium Hyaluronate and Sodium Lactate
Combines Matrixyl™ 3000 with a lipid-rich blend of botanical oils, Shea Butter and Squalane
Helps dry and tired-looking skin feel softer and more resilient by morning

Matrixyl™ 3000 — biomimetic peptide complex
Matrixyl™ 3000 is an established peptide technology developed by Sederma, part of Croda. The complex is associated with two matrikine-inspired peptides: Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7
Matrikines are messenger peptides associated with processes involved in the skin's extracellular matrix. Croda positions MATRIXYL® 3000 as an anti-wrinkle complex developed to address visible signs associated with chronological skin aging and photo-damage.
Croda also uses the ingredient in formulations positioned for improved wrinkle appearance, tone, firmness and elasticity.

Lipid Recovery Complex
Cranberry Seed Oil, Jojoba Seed Oil, Safflower Seed Oil, Shea Butter and Squalane create the nourishing core of our cream.
Rather than treating peptide care as an isolated anti-aging step, the formula surrounds the peptide complex with emollient lipids selected to soften the skin, reduce the feeling of dryness and support comfort throughout the night.

Sodium Hyaluronate + Humectant Support
Sodium Hyaluronate, Glycerin and Sodium Lactate help attract and retain water at the skin surface.
This hydration system complements the lipid phase, allowing Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate to address both the water and emollient components of overnight skin comfort.

I wanted to create a night cream for the evenings when skin does not need another aggressive treatment — it needs support.

Daily exposure, cleansing, active ingredients, environmental conditions and simple moisture loss can leave skin feeling dry, tight or less comfortable by the end of the day. At the same time, fine lines and uneven texture often become more visible when skin loses hydration and suppleness.

For Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate, I wanted peptide care to sit inside a genuinely nourishing night formula rather than in a light cream that focuses only on one active.

Matrixyl™ 3000 became the targeted peptide technology, while Cranberry, Jojoba and Safflower Oils, Shea Butter and Squalane were selected to give the formula its recovery-focused character.

Glycerin, Sodium Hyaluronate and Sodium Lactate support hydration, while vitamin E and Calcium PCA complete the skin-conditioning profile.

The result is a cream designed to be the final, comforting step of the evening routine: peptide-focused enough to address visible signs of aging, but rich enough to leave dry and tired skin feeling replenished by morning.

Within the AMERÍN Longevity Protocol, our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate is the overnight recovery and replenishment step — supporting the conditions that help skin maintain smoothness, suppleness and comfort over time.

$57.00 $114.00/100ml

A nourishing night cream formulated with Matrixyl™ 3000, Sodium Hyaluronate and a lipid-rich blend of Cranberry, Jojoba and Safflower Oils, Shea Butter and Squalane.

Designed for skin that feels dry, tired or less supple, our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate combines advanced peptide care with humectants and emollients to support smoother-looking texture, lasting comfort and a softer, better-conditioned complexion by morning.

Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate helps skin feel softer, smoother and more comfortable while supporting a visibly more supple and refined complexion.

Matrixyl™ 3000 provides peptide-focused care for visible signs associated with skin aging and helps support the appearance of smoother and firmer skin.
Glycerin, Sodium Hyaluronate and Sodium Lactate contribute hydration, helping fine dehydration lines appear softened as the skin becomes better moisturized.
Cranberry, Jojoba and Safflower Oils, Shea Butter and Squalane replenish the emollient phase of the formula, reducing the sensation of dryness and leaving skin softer and more flexible.

By morning, skin feels nourished and conditioned and appears smoother, more rested and more supple.

Rich, creamy and cocooning, with a smooth, cushioned finish.

Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate has a more nourishing texture than a conventional daily moisturizer and was developed specifically for evening use.

Jojoba Oil, Safflower Oil, Cranberry Seed Oil, Shea Butter and Squalane give the cream softness and richness, while Dimethicone contributes glide and a smooth, protective-feeling finish.

The texture melts into the skin and leaves a conditioned layer of comfort without the dense waxiness of a traditional balm.

It is particularly suited to skin that feels depleted, dry or less comfortable at the end of the day.

Suitable for normal, dry, dehydrated and mature-looking skin, particularly when concerns include:

dryness
reduced suppleness
fine lines
uneven-looking texture
loss of comfort
tired-looking skin
a need for richer overnight care

It is particularly suitable for routines that already contain more active treatment steps and need a nourishing final cream.

Very oily skin may find the lipid-rich texture heavier than necessary.

If your skin is very sensitive or reactive, patch test before regular use because the formula contains fragrance.

Apply in the evening to clean skin as the final cream step of your skincare routine.
Spread over the face and neck and massage gently until absorbed.
Leave on overnight.

Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate can be used after hydrating, peptide or antioxidant serums.

It can also be used on recovery evenings between stronger treatments such as retinoids or exfoliating acids.

If your skin is irritated from excessive use of active products, simplify the routine and avoid continuing irritating actives until skin comfort has returned.

General warnings: For external use only. Avoid contact with eyes. In case of contact, rinse thoroughly with water. Discontinue use if irritation or redness occurs. Keep out of reach of children.

Aqua, Simmondsia Chinensis (Jojoba) Seed Oil, Glycerin, Carthamus Tinctorius (Safflower) Seed Oil,Butyrospermum Parkii (Shea) Butter, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Vaccinium Macrocarpon (Cranberry) Seed Oil, Cetyl Palmitate, PEG-100 Stearate, Ceteareth-20, Butylene Glycol, Calcium PCA, Squalane, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Hyaluronate, Tocopheryl Acetate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Laureth-4, Carbomer, Polysorbate 60, Sorbitan Isostearate, Sodium Lactate, Polysorbate 20, Phenoxyethanol, Ethylhexylglycerin, Potassium Sorbate, Parfum, Hexyl Cinnamal, Geranyl Acetate, Amyl Salicylate, Dimethyl Phenethyl Acetate, Citronellol, Vanillin, Linalool, Linalyl Acetate, Disodium EDTA

In your attention: We do our best to keep the INCI list updated. However, ingredients may occasionally change. Please refer to the product label for the latest details.

Warnings: Do not use if you are allergic to one of the INCI contained by the product.

Quantity: 50.0 mL
PAO: 12 months
SKU: 1004
GTIN: 5940031115692
Made in Europe with love for your skin

Pairs well with the following products

Complements a skin longevity routine focused on recovery, comfort and visible well-aging support

Helps reduce the feeling of dryness with cranberry oil, jojoba oil, safflower oil, shea butter and squalane

Supports hydration with glycerin, sodium hyaluronate, calcium PCA and sodium lactate

Helps skin feel softer, more nourished and more comfortable overnight

Helps support smoother-looking skin through Matrixyl™ 3000 peptide care

Results you’ll love:

Immediately after use
Skin feels softer, more nourished and more comfortable.
The rich emollient base reduces the feeling of dryness and leaves the complexion smooth, supple and conditioned.

With consistent use
Skin appears smoother, more supple and visibly better conditioned.
Fine lines and uneven-looking texture may appear softened, while the complexion feels better hydrated and more resilient.
Matrixyl™ 3000 supports the formula's long-term peptide care for visible smoothness and firmness. Croda positions MATRIXYL® 3000 for anti-wrinkle care and uses it in formulations targeting wrinkle smoothing, firmness and elasticity.

In a skin longevity routine
Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate acts as the overnight recovery and replenishment step within the AMERÍN Longevity Protocol.
Its role is to combine peptide-focused care with hydration and lipid-rich nourishment, supporting several visible qualities associated with well-conditioned skin: smoothness, suppleness, comfort and resilience.

It is particularly relevant on evenings when the routine needs recovery rather than another intensive resurfacing or renewal step.

LONGEVITY PERSPECTIVE:

Skin longevity depends not only on how aggressively visible signs of aging are treated, but also on how consistently skin comfort, hydration and overall condition are maintained.

A routine built entirely around intensive actives can overlook this recovery dimension. Our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate was developed to restore that balance.

Matrixyl™ 3000 provides targeted peptide care for visible signs of skin aging, while Jojoba, Safflower and Cranberry Oils, Shea Butter and Squalane create a lipid-rich conditioning system.
Glycerin, Sodium Hyaluronate and Sodium Lactate support hydration, while vitamin E contributes antioxidant-focused care.
Together, these elements create an overnight formula that supports visible smoothness without separating well-aging care from nourishment and comfort.

Within the AMERÍN Longevity Protocol, our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate is therefore the recovery night cream. Its role is to maintain a well-conditioned, hydrated and supple skin environment between more intensive renewal steps and to support the visible qualities associated with resilient skin over time.

Longevity is not only about stimulating renewal. It also depends on knowing when the skin needs replenishment.

Two clear circular petri dishes on a white background containing glossy droplets of pale beige and pale yellow liquid, likely cosmetic or skincare serum/oil droplets.

Main ingredients

Matrixyl™ 3000
A peptide technology developed by Sederma/Croda and associated with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7.
Croda describes MATRIXYL® 3000 as a matrikine anti-wrinkle complex and uses it in formulations targeting visible wrinkle smoothing, firmness, tone and elasticity.

Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7
The two peptide components associated with Matrixyl™ 3000.
Together, they form the targeted peptide system at the heart of Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate and support the formula's smoothing and well-aging direction.

Cranberry Seed Oil
A nourishing botanical oil that contributes emollience and softness.
It helps reduce the feeling of dryness and gives to the Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate part of its distinctive overnight recovery profile.

Jojoba Seed Oil
A skin-compatible emollient that helps soften the skin and maintain suppleness

Safflower Seed Oil
A lightweight botanical oil that supports softness and helps reduce the sensation of dryness.
It contributes to the cream's lipid-rich but spreadable texture.

Shea Butter
A rich emollient that helps soften and comfort dry skin.
It reinforces the nourishing character of the Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate and contributes to the cushioned night-cream texture.

Squalane
A skin-compatible emollient that helps maintain softness, suppleness and barrier comfort.

Sodium Hyaluronate
A form of hyaluronic acid that helps attract and retain water at the skin surface.
It contributes to hydration and a smoother, more supple skin appearance.

Glycerin
A humectant that attracts water to the skin surface and helps maintain hydration throughout the night.

Sodium Lactate
A humectant associated with the skin's natural moisturizing system.
It complements Glycerin and Sodium Hyaluronate in supporting moisture retention and comfort.

Tocopheryl Acetate
A vitamin E derivative included for antioxidant and skin-conditioning support.

Calcium PCA
A mineral PCA ingredient used for skin-conditioning support.
It complements the formula's hydration and recovery-focused profile without being positioned as a primary anti-aging active.

Dimethicone
Helps improve glide and creates a smooth, protective-feeling finish that supports comfort and reduces the sensation of dryness.

A close-up of a smooth, creamy white product, likely a skincare cream or lotion, swirled in a circular motion.

FAQ

What is DEFEND Peptide Recovery Night Cream designed for?
Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate is designed for skin that feels dry, tired, less supple or in need of richer overnight support.
It combines Matrixyl™ 3000 peptide care with hydration and a substantial blend of botanical oils, Shea Butter and Squalane.

What is Matrixyl™ 3000?
Matrixyl™ 3000 is a peptide technology developed by Sederma, part of Croda.
It is associated with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 and is positioned by Croda as a matrikine anti-wrinkle complex for visible signs of skin aging.

What are matrikines?
Matrikines are peptide fragments associated with signalling processes related to the extracellular matrix.
Matrixyl™ technology was developed around the concept of using biomimetic peptide signals in cosmetic well-aging care.

Does Matrixyl™ 3000 stimulate collagen?
Supplier materials for the Matrixyl family describe matrikine peptides in relation to skin matrix and repair signalling.
For consumer communication, we prefer to position our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate around the validated cosmetic outcomes relevant to the product — smoother-looking skin, visible wrinkle care, firmness and elasticity — rather than claim a specific level of collagen stimulation for the finished cream.

Why is DEFEND | Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate called a recovery night cream?
Its formula combines peptide care with a high proportion of emollient ingredients and botanical oils.
The objective is to support nourishment, hydration, softness and comfort overnight, particularly between more intensive active-treatment evenings.

Can I use it every night?
Yes. Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate can be used every evening as the final step of your skincare routine.

Is it suitable for dry skin?
Yes. The formula is particularly suitable for normal-to-dry and dehydrated skin and contains Jojoba Oil, Safflower Oil, Cranberry Seed Oil, Shea Butter, Squalane, Glycerin and Sodium Hyaluronate.

Is it suitable for oily skin?
Very oily skin may find the texture richer than necessary.
Our Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate is primarily designed for normal, dry and dehydrated skin.

Can I use it after a retinoid?
Yes. Its nourishing profile makes it suitable as the final moisturizing step after a retinoid when your skin tolerates the combination.
If the retinoid causes significant irritation, reduce the frequency of the active rather than relying on moisturizer to compensate for excessive irritation.

Can I use it after exfoliating acids?
Yes, when your skin tolerates the routine. Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate can be particularly useful as the nourishing cream step following active treatment, although very sensitive skin may prefer to alternate intensive acids with recovery evenings.

Does it contain hyaluronic acid?
Yes. The formula contains Sodium Hyaluronate, a form of hyaluronic acid used to support surface hydration and suppleness.

Is it suitable for sensitive skin?
The formula contains multiple nourishing and hydrating ingredients, but it also contains fragrance.
Very sensitive or reactive skin should patch test before regular use.

Where does DEFEND | Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate fit within the AMERÍN Longevity Protocol?
Peptide Recovery Night Cream with Matrixyl™ 3000 and Sodium Hyaluronate is the overnight recovery and replenishment step.
It combines peptide care with hydration and lipid-rich nourishment to support smoothness, suppleness and skin comfort, making it particularly useful between more intensive renewal-focused steps of the protocol.