DEFEND | Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™

Name: DEFEND | Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™
Brand: amerín
SKU: 1008
Price: 65.00 USD
Availability: InStock

Benefits: firming support + smoother-looking skin | Skin type: all skin types | Usage: morning & evening

A multi-active serum-emulsion combining Matrixyl™ 3000 with VitaSource™ to address visible loss of firmness, reduced elasticity, dehydration and changes in overall skin quality.

Matrixyl™ 3000 provides targeted peptide care for visible wrinkles, smoothness and firmness, while VitaSource™ introduces a longevity-focused botanical technology developed around cellular senescence and skin resilience. Soluble Collagen, Sodium Hyaluronate, Panthenol, Squalane and NMF-related humectants complete the formula with hydration, softness and comfort.

Skin feels nourished and supple and appears smoother, firmer and visibly better conditioned.

Helps improve visible firmness and elasticity
Supports smoother-looking texture and fine-line care
Combines Matrixyl™ 3000 peptide technology with VitaSource™ longevity-focused care
Provides multi-level hydration with Sodium Hyaluronate, Sodium PCA, Sodium Lactate and Glycerin
Supports softness and comfort with Squalane and botanical oils
Helps tired, dry and mature-looking skin appear more resilient and revitalized

VitaSource™ — longevity-focused Baicalin technology
VitaSource™ is a cosmetic active developed by Provital from Scutellaria baicalensis and standardized around Baicalin. Unlike ingredients designed primarily to provide an immediate surface effect, VitaSource™ was developed around biological processes associated with cellular senescence.
Provital describes the active as acting through telomerase-related mechanisms and positions it for improving skin firmness, elasticity and microrelief. Supplier testing at 1.5% over 56 days reported improvements of approximately 10.9–12.5% in firmness, 10.4–12.4% in elasticity and a 13% reduction in anisotropy, interpreted by the supplier as improved organization of skin microrelief.

Matrixyl™ 3000 — biomimetic peptide complex
Matrixyl™ 3000 is a peptide technology developed by Sederma, part of Croda.
The complex is associated with two matrikine-inspired peptides: Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. Croda positions Matrixyl™ 3000 as an anti-wrinkle matrikine complex and associates the technology with visible wrinkle smoothing, tone and elasticity.
Together, Matrixyl™ 3000 and VitaSource™ give our Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ its dual longevity identity: peptide-focused care for visible structural signs of aging combined with a botanical active specifically developed around cellular aging mechanisms.

NMF-Inspired Hydration System
Glycerin, Sodium PCA, Sodium Lactate, Sodium Hyaluronate, Panthenol and complementary humectants support water balance at the skin surface. This extensive hydration system is particularly relevant because visible firmness and elasticity are influenced by the condition and hydration of the skin, not only by targeted anti-aging actives.

I wanted to create a serum that approached skin longevity more directly.

For me, longevity skincare should not mean simply adding the word “anti-aging” to another hydrating formula. It should bring together ingredients that address different aspects of how skin changes over time.

One of these changes is visible loss of firmness and elasticity. Another is the gradual decline in skin quality — hydration, suppleness, smoothness and resilience.

This is why I chose to combine two technologies with different but complementary roles.

Matrixyl™ 3000 provides targeted peptide care for the visible structural signs associated with skin aging.

VitaSource™ was selected for a different reason. Its development around Baicalin, cellular senescence and telomerase-related pathways made it particularly relevant to the longevity philosophy I wanted to build into AMERÍN.

Around these actives, I wanted the skin to receive substantial hydration and comfort. Soluble Collagen, Sodium Hyaluronate, Sodium PCA, Sodium Lactate, Panthenol and Glycerin provide humectant support, while Squalane, Cranberry, Meadowfoam, Avocado and Sweet Almond Oils create a nourishing emollient layer.

The result is a serum-emulsion designed not only to address fine lines or firmness independently, but to support the broader visible qualities associated with well-maintained skin: elasticity, smoothness, hydration, suppleness and resilience.

Within the AMERÍN Longevity Protocol, DEFEND Serum is the targeted longevity and structural-support step.

$65.00 $216.67/100ml

Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ is a firming serum-emulsion designed for skin that looks tired, less elastic, dry or marked by visible signs of aging.

The formula combines Matrixyl™ 3000, VitaSource™, Soluble Collagen, Sodium Hyaluronate, Panthenol, Squalane, Cranberry Seed Oil, Meadowfoam Seed Oil, Avocado Oil, Sweet Almond Oil and an NMF-inspired hydration system to help skin look smoother, firmer and better conditioned.

Matrixyl™ 3000 is associated with the peptide pairing Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, used in cosmetic formulas for smoother-looking skin and visible well-aging care. VitaSource™ is associated with Baicalin, a plant-derived cosmetic active used for antioxidant-focused and skin-conditioning care.

The texture is more nourishing than a water serum, making it suitable for a DEFENSE routine focused on hydration, firmness, comfort and resilience.

Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ helps skin appear firmer, smoother and more elastic while improving hydration, suppleness and overall visible skin quality.

Matrixyl™ 3000 provides targeted peptide care focused on visible wrinkles, smoothness and firmness.
VitaSource™ extends the formula beyond conventional peptide skincare by introducing a longevity-focused active developed around cellular senescence and telomerase-related mechanisms. Provital associates VitaSource™ with improved firmness, elasticity and skin microrelief.
Soluble Collagen, Sodium Hyaluronate, Sodium PCA, Sodium Lactate, Panthenol and Glycerin help maintain hydration, supporting a smoother and more supple surface.
Squalane and botanical oils reduce the feeling of dryness and help maintain softness and comfort.

With consistent use, the complexion appears smoother, firmer, more hydrated and visibly better conditioned, with improved suppleness and a more resilient overall appearance.

Milky, nourishing and serum-emulsion-like.

Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ has more body than a traditional water serum, while remaining lighter and easier to layer than a conventional face cream.

Squalane, Cranberry Oil, Meadowfoam Oil, Avocado Oil, Sweet Almond Oil and olive-derived emollients create a smooth, cushioned glide.

The serum settles into a soft and comfortable finish that makes it particularly suitable for normal, dry and dehydrated skin.

It combines the concentration of an active serum with the comfort of a lightweight emulsion.

Suitable for normal, dry, dehydrated and mature-looking skin, particularly when concerns include:

reduced firmness
loss of elasticity or suppleness
fine lines
dehydration
dull or tired-looking skin
reduced skin comfort
visible signs of aging
a desire for longevity-focused skincare

It can also be incorporated into combination-skin routines if a more nourishing serum texture is preferred.
Very oily skin may prefer a lighter aqueous formula.
If your skin is very sensitive or reactive, patch test before regular use because the formula contains fragrance, listed fragrance allergens, Retinyl Palmitate and multiple botanical ingredients.

Apply 2–3 drops to clean skin morning and/or evening.
Spread over the face and neck and gently massage until absorbed.
Follow with your regular face cream according to your skin's needs.
In the morning, complete the routine with broad-spectrum SPF.

Because the formula contains Retinyl Palmitate, sensitive skin using stronger retinoids or intensive exfoliating acids may prefer to alternate active routines rather than layer them simultaneously.

General warnings: For external use only. Avoid contact with eyes. In case of contact, rinse thoroughly with water. Discontinue use if irritation or redness occurs. Keep out of reach of children.

Aqua, Glycerin, Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables, Squalane, Soluble Collagen, Panthenol, Propanediol, Dimethicone, Polyacrylate Crosspolymer-11, Vaccinium Macrocarpon (Cranberry) Seed Oil, Limnanthes Alba Seed Oil, Sodium Hyaluronate, Butylene Glycol, Persea Gratissima Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Sodium PCA, Panax Ginseng Root Extract, Glycine Soja Germ Extract, Hydrolyzed Serum Protein, Aminobutyric Acid, PEG-40 Hydrogenated Castor Oil, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tocopherol Acetate, Baicalin, Enteromorpha Compressa Extract, Silybum Marianum Fruit Extract, Ocimum Sanctum Leaf Extract, Retinyl Palmitate , Calcium Sulfate, Magnesium Sulfate, Copper Sulfate, Potassium Sulfate, Zinc Sulfate, Manganese Sulfate , Ferric Sulfate, Polysorbate 20, Sodium Lactate, Carbomer, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Potassium Sorbate, Isopropyl Alcohol , Citric Acid, Parfum, Benzyl Salicylate, Hexyl Cinnamal

In your attention: We do our best to keep the INCI list updated. However, ingredients may occasionally change. Please refer to the product label for the latest details.

Warnings: Do not use if you are allergic to one of the INCI contained by the product.

Quantity: 30.0 mL
PAO: 12 months
SKU: 1008
GTIN: 5940031115685
Made in Europe with love for your skin

Pairs well with the following products

Complements a longevity routine focused on firmness, hydration, barrier comfort and visible well-aging care

Helps skin feel softer, more comfortable and better conditioned

Supports hydration through glycerin, sodium hyaluronate, sodium PCA and sodium lactate

Helps improve the look of fine lines, dryness and uneven texture

Helps support a firmer and more elastic-looking complexion

Results you’ll love:

Immediately after use
Skin feels softer, smoother and more hydrated.
The serum-emulsion texture improves comfort and suppleness and leaves the complexion with a nourished, well-conditioned finish.

With consistent use
Skin appears smoother, firmer and more supple.
Improved hydration contributes to a more refined skin surface, while the complexion may appear more elastic, better conditioned and less tired.
Matrixyl™ 3000 supports the peptide-focused firming direction of the formula, while VitaSource™ provides the longevity-focused dimension associated by its supplier with firmness, elasticity and improved skin microrelief.

In a skin longevity routine
DEFEND | Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ is the targeted longevity and structural-support step within the AMERÍN Longevity Protocol.
The formula combines peptide technology with a botanical longevity active, hydration, lipid support and antioxidant-focused care. This allows DEFEND | Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ to address several visible dimensions of skin quality simultaneously: firmness, elasticity, hydration, smoothness, suppleness and resilience.

LONGEVITY PERSPECTIVE:

Skin longevity is not simply the absence of wrinkles. It reflects the ability of skin to maintain qualities such as firmness, elasticity, hydration, suppleness and an organized, smooth-looking surface over time.

Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ was created specifically around this broader perspective.

Matrixyl™ 3000 provides the peptide dimension, targeting visible signs associated with changes in the skin matrix and supporting smoother, firmer-looking skin.
VitaSource™ takes the formula further into the longevity space. Provital developed the active around Baicalin and cellular senescence, with a mechanism linked to telomerase activity. Supplier in vitro work reported a 10% increase in fibroblast duplicative capacity before senescence, while the in vivo study at 1.5% over 56 days reported improvements in firmness, elasticity and skin microrelief.
The rest of the formula creates the environment required for this advanced active system to sit within a comfortable daily routine. Soluble Collagen, Sodium Hyaluronate, Sodium PCA, Sodium Lactate, Panthenol and Glycerin support hydration. Squalane and botanical oils maintain softness and suppleness. Vitamin E and botanical extracts complement the antioxidant and conditioning profile.

Within the AMERÍN Longevity Protocol, our Longevity Firming Serum with Matrixyl™ 3000 and VitaSource™ is therefore more than a firming serum. It is the formula specifically designed to connect visible firming care with the biological concept of skin longevity.

Its role is to help preserve the visible qualities associated with skin that continues to look strong, supple and well maintained over time.

Two clear circular petri dishes on a white background containing glossy droplets of pale beige and pale yellow liquid, likely cosmetic or skincare serum/oil droplets.

Main ingredients

VitaSource™
VitaSource™ is a longevity-focused cosmetic active developed by Provital from Scutellaria baicalensis and standardized around Baicalin. Provital positions the ingredient around delaying cellular senescence through telomerase-related activity and improving firmness, elasticity and skin microrelief.
Supplier testing at 1.5% over 56 days reported measurable improvements in firmness and elasticity together with improved skin microrelief.

Matrixyl™ 3000
A matrikine peptide complex developed by Sederma/Croda.
Associated with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, Matrixyl™ 3000 is positioned for anti-wrinkle care and improved visible smoothness, tone and elasticity.

Soluble Collagen
A skin-conditioning form of collagen that helps support surface hydration and softness. It contributes to a smoother and more supple skin feel and complements the formula's firming and hydration direction.

Sodium Hyaluronate
A form of hyaluronic acid that helps attract and retain water at the skin surface. It supports hydration, suppleness and a smoother, fuller-looking complexion.

Glycerin + Sodium PCA + Sodium Lactate
An NMF-inspired combination of humectants designed to support water retention and skin comfort. Together, they contribute to the hydrated and flexible skin environment important for visible smoothness and suppleness.

Panthenol
Provitamin B5 supports hydration, softness and comfort. It balances the active longevity and peptide systems with skin-conditioning care.

Squalane
A skin-compatible emollient that helps maintain softness, suppleness and barrier comfort without excessive heaviness.

Cranberry Seed Oil
A nourishing botanical oil that helps soften the skin and reinforce the serum's lipid-rich conditioning profile.

Meadowfoam Seed Oil
A stable emollient oil that contributes softness, comfort and a smooth skin feel.

Avocado Oil
A nourishing botanical emollient that helps reduce the sensation of dryness and supports skin suppleness.

Sweet Almond Oil
A skin-conditioning oil that contributes softness and comfort.

Panax Ginseng Root Extract
A botanical extract used to complement the revitalizing and conditioning profile of the serum.

Tocopheryl Acetate
A vitamin E derivative incorporated for antioxidant and skin-conditioning support.

Retinyl Palmitate
A vitamin A ester used in cosmetic well-aging formulas to support a smoother and more refined-looking skin surface.

Botanical + Marine Complex
Enteromorpha Compressa, Milk Thistle and Holy Basil extracts complement the broader conditioning and antioxidant-focused profile of the formula.

A close-up of a smooth, creamy white product, likely a skincare cream or lotion, swirled in a circular motion.

FAQ

What is this serum designed for?
It is designed for skin that looks tired, less firm, dry, dehydrated or marked by visible signs of aging.

What is Matrixyl™ 3000?
Matrixyl™ 3000 is a trademarked peptide complex associated with Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. In cosmetic formulas, it supports smoother-looking skin and visible well-aging care.

What is VitaSource™?
VitaSource™ is associated with Baicalin, a cosmetic active derived from Scutellaria baicalensis.

Is this a water serum or a richer serum?
It is closer to a serum-emulsion. The formula contains squalane, cranberry oil, meadowfoam oil, avocado oil, sweet almond oil and olive-derived emollients, so the texture is more nourishing than a classic water serum.

Can I use it every day?
Yes. It can be used daily, preferably in the evening or in the morning followed by SPF.

Does it contain retinoids?
Yes. It contains Retinyl Palmitate, a cosmetic vitamin A derivative.

Is it suitable for dry skin?
Yes. The formula contains humectants, emollients, oils, squalane, panthenol and sodium hyaluronate, which support hydration, softness and comfort.

Is it suitable for oily skin?
Very oily skin may find the texture too rich. It is better suited to normal, dry, dehydrated or mature-looking skin.

Does it contain fragrance?
Yes. The formula contains parfum and listed fragrance allergens: Benzyl Salicylate and Hexyl Cinnamal.

Is it suitable for sensitive skin?
The formula contains comfort-supporting ingredients, but it also contains fragrance, fragrance allergens, Retinyl Palmitate, botanical extracts and peptide ingredients. If your skin is very sensitive or reactive, patch test before use.

Can I use it with acids or stronger retinoids?
If your skin is sensitive, avoid using it in the same routine with exfoliating acids or high-strength retinoids. Alternate routines if needed.